Therapeutic targets for hepatocellular carcinoma identified using proteomics and Mendelian randomization

Abstract excerpt

BACKGROUND AND AIM: Hepatocellular carcinoma (HCC) emerges as a formidable malignancy marked by elevated morbidity and mortality rates, coupled with a dismal prognosis. The revelation of gene-protein associations has presented an avenue for the exploration of novel therapeutic targets. METHODS: Pooling plasma proteomic data (seven published GWAS) and HCC data (DeCODE cohort), we applied MR to identify potential...

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