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Article

Genetic prediction of the relationship between mitochondrial proteins and diabetic polyneuropathy risk: a Mendelian randomization study.

Endocrine research - 1 Nov 2025

Wang Zixiao, Hu Yifang, Wei Yiren, Xue Cheng, Hu Yanyan, Wang Yifei, Wu Chuyan, Jiang Feng, Wang Fang

Abstract excerpt

BACKGROUND: This Mendelian Randomization (MR) study investigates the causal relationships between mitochondrial proteins and Diabetic polyneuropathy (DPN). METHODS: Using a two-sample MR design with data from FINNGEN (1048 DPN cases, 374,434 controls) and 63 mitochondrial proteins from GWAS datasets. Analyses used the Inverse Variance Weighted (IVW) method, MR-Egger regression, and weighted medians, with...

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Share to Diabetic Neuropathies
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Polymorphism, Single Nucleotide

Source

Identifiers

PMID: 40920026
DOI: 10.1080/07435800.2025.2557991

Genes

COA3
NFU1
SARS2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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