Body Composition-Driven Phenotyping Reveals Obesity and Cardiometabolic Heterogeneity in Children Using a Tree-Like Representation.

doi:10.2337/db26-0136

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Article

Body Composition-Driven Phenotyping Reveals Obesity and Cardiometabolic Heterogeneity in Children Using a Tree-Like Representation.

Diabetes - 1 Oct 2026

Xiao Pei, Cheng Hong, Xiong Jingfan, Yan Yinkun, Liu Junting, Liu Li, Dong Hongbo, Li Yan, Ye Peiyu, Fu Liwan, Gao Liwang, Chen Fangfang, Shan Xinying, Lan Lina, Li Yanyan, Mi Jie

Abstract excerpt

Traditional measures such as BMI do not fully capture obesity-related metabolic risks. Here, we examined DXA-derived body composition patterns in children (n = 11,238) using the discriminative dimensionality reduction tree algorithm, which was validated in an independent cohort (n = 2,001). The tree structure revealed a continuous landscape of body composition phenotypes, with distinct spatial gradients for fat...

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Topics

Humans
Body Composition
Phenotype
Child
Male
Female

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Obesity

Body Mass Index

Absorptiometry, Photon

Algorithms

Triglycerides

Adolescent

Adiposity

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Open in PubMed

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PMID: 42606340
DOI: 10.2337/db26-0136

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