Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mutant NPM1-regulated estrogen signaling promotes leukemia cell survival by upregulating HGF and represents a therapeutic vulnerability.

Biochemical pharmacology - 1 May 2026

Yang Jing, Ren Jun, Tao Tinglu, Peng Meixi, Zhao Wen, Xiao Qiaoling, Wu Nan, Chen Xinyi, Yuan Zihao, Zu Yi, Cheng Wei, Zhang Ling

Abstract excerpt

Acute myeloid leukemia (AML) with mutated nucleophosmin 1 (NPM1) presents therapeutic challenge and exhibits a striking female predominance in clinical. However, the contribution of gender-specific factors, such as sex hormones to the pathogenesis and therapeutic implications in NPM1-mutated AML remains elusive. In the present study, we found that NPM1-mutated AML showed female bias, particularly among the young,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Survival
Share to Estradiol

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Estrogen Receptor alpha

Share to Estrogens

Share to Leukemia, Myeloid, Acute

Share to Nuclear Proteins

Share to Nucleophosmin

Share to Up-Regulation

Source

Identifiers

PMID: 41679667
DOI: 10.1016/j.bcp.2026.117796

Genes

NPM1
HGF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mutant NPM1-regulated estrogen signaling promotes leukemia cell survival by upregulating HGF and represents a therapeutic vulnerability.PMID 41679667Read ↗

NPM1-Mutated AML: Deciphering the Molecular and Clinical Puzzle in the Era of Novel Treatment StrategiesSemantic proximity Read ↗

NPM1-mutated acute myeloid leukemia: from bench to bedside.Semantic proximity Read ↗

Nucleophosmin 1: from its pathogenic role to a tantalizing therapeutic target in acute myeloid leukemia.Semantic proximity Read ↗

Menin: from molecular insights to clinical impactSemantic proximity Read ↗

Nucleophosmin mutations in acute myeloid leukemia: a tale of protein unfolding and mislocalization.Semantic proximity Read ↗

The potential role of nucleophosmin (NPM1) in the development of cancer.Semantic proximity Read ↗

Optineurin enhances the chemoresistance by activating mitophagy in acute myeloid leukemia with NPM1 mutation.Semantic proximity Read ↗

Menin Inhibitors in Acute Myeloid Leukemia-What Does the Future Hold?Semantic proximity Read ↗

HER2-Driven Breast Tumorigenesis Relies upon Interactions of the Estrogen Receptor with Coactivator MED1.Semantic proximity Read ↗

NPM and NPM-MLF1 interact with chromatin remodeling complexes and influence their recruitment to specific genes.Semantic proximity Read ↗

Cytoplasmic Expression of TP53INP2 Modulated by Demethylase FTO and Mutant NPM1 Promotes Autophagy in Leukemia Cells.Semantic proximity Read ↗

Disruption of the NHR4 domain structure in AML1-ETO abrogates SON binding and promotes leukemogenesisSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.