Article
Microbial metabolite butyrate facilitates M2 macrophage polarization and function.
Scientific reports - 20 Apr 2016
Ji Jian, Shu Dingming, Zheng Mingzhu, Wang Jie, Luo Chenglong, Wang Yan, Guo Fuyou, Zou Xian, Lv Xiaohui, Li Ying, Liu Tianfei, Qu Hao
Abstract excerpt
Metabolites from intestinal microbes modulate the mucosal immune system by regulating the polarization and expansion of T cells. Whether the microbial metabolites influence macrophage polarization, however, is poorly understood. Here, we show that the large bowel microbial fermentation product, butyrate, facilitates M2 macrophage polarization, in vitro and in vivo. The supernatant from butyrate-treated M2...
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