Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Comparative analysis between 2D and 3D colorectal cancer culture models for insights into cellular morphological and transcriptomic variations

26 Oct 2023

Abstract excerpt

Drug development is a time-consuming and expensive process, given the low success rate of clinical trials. Now, anticancer drug developments have shifted to three-dimensional (3D) models which are more likely to mimic tumor behavior compared to traditional two-dimensional (2D) cultures. A comparative study among different aspects was conducted between 2D and 3D cultures using colorectal cancer (CRC) cell lines,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to 3D Printing in Biomedical Research
Share to Cancer Cells and Metastasis
Share to Cellular Mechanics and Interactions

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 37884554
DOI: 10.1038/s41598-023-45144-w

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Comparative analysis between 2D and 3D colorectal cancer culture models for insights into cellular morphological and transcriptomic variationsPMID 37884554Read ↗

Comparative Study of Colorectal Cancer Cell Lines Cultured in Two- and Three- Dimensional Models: Insights into Cellular Morphologies, Drug Responsiveness and TranscriptomicsSemantic proximity Read ↗

Three-Dimensional 3D Culture Models in Gynecological and Breast Cancer ResearchSemantic proximity Read ↗

Spheroids and organoids derived from colorectal cancer as tools for in vitro drug screeningSemantic proximity Read ↗

Colorectal Cancer Patient‐Derived 2D and 3D Models Efficiently Recapitulate Inter‐ and Intratumoral HeterogeneitySemantic proximity Read ↗

2D and 3D cell cultures – a comparison of different types of cancer cell culturesSemantic proximity Read ↗

Three-dimensional in vitro culture models in oncology researchSemantic proximity Read ↗

Two-Dimensional and Spheroid-Based Three-Dimensional Cell Culture Systems: Implications for Drug Discovery in CancerSemantic proximity Read ↗

Contributions of 3D Cell Cultures for Cancer Research.Semantic proximity Read ↗

Development of a Colorectal Cancer 3D Micro-tumor Construct Platform From Cell Lines and Patient Tumor Biospecimens for Standard-of-Care and Experimental Drug ScreeningSemantic proximity Read ↗

Systematic evaluation of colorectal cancer organoid system by single-cell RNA-Seq analysisSemantic proximity Read ↗

Impact of the 3D microenvironment on phenotype, gene expression, and EGFR inhibition of colorectal cancer cell lines.Semantic proximity Read ↗

2D- and 3D-Based Intestinal Stem Cell Cultures for Personalized MedicineSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.