Effect of Genotype-Guided Oral P2Y12 Inhibitor Selection vs Conventional Clopidogrel Therapy on Ischemic Outcomes After Percutaneous Coronary Intervention: The TAILOR-PCI Randomized Clinical Trial.

doi:10.1001/jama.2020.12443

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Article

Effect of Genotype-Guided Oral P2Y12 Inhibitor Selection vs Conventional Clopidogrel Therapy on Ischemic Outcomes After Percutaneous Coronary Intervention: The TAILOR-PCI Randomized Clinical Trial.

JAMA - 25 Aug 2020

Pereira Naveen L, Farkouh Michael E, So Derek, Lennon Ryan, Geller Nancy, Mathew Verghese, Bell Malcolm, Bae Jang-Ho, Jeong Myung Ho, Chavez Ivan, Gordon Paul, Abbott J Dawn, Cagin Charles, Baudhuin Linnea, Fu Yi-Ping, Goodman Shaun G, Hasan Ahmed, Iturriaga Erin, Lerman Amir, Sidhu Mandeep, Tanguay Jean-Francois, Wang Liewei, Weinshilboum Richard, Welsh Robert, Rosenberg Yves, Bailey Kent, Rihal Charanjit

Abstract excerpt

Importance: After percutaneous coronary intervention (PCI), patients with CYP2C19*2 or *3 loss-of-function (LOF) variants treated with clopidogrel have increased risk of ischemic events. Whether genotype-guided selection of oral P2Y12 inhibitor therapy improves ischemic outcomes is unknown. Objective: To determine the effect of a genotype-guided oral P2Y12 inhibitor strategy on ischemic outcomes in CYP2C19 LOF...

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PMID: 32840598
DOI: 10.1001/jama.2020.12443
PMCID: PMC7448831

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