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Article

Inferring context-specific site variation with evotuned protein language models.

NAR genomics and bioinformatics - 1 Mar 2026

Lytras Spyros, Strange Adam, Ito Jumpei, Sato Kei

Abstract excerpt

Multiple sequence alignments (MSAs) have been traditionally used for making inferences about site-specific diversity in proteins. Recent advancements in the field of artificial intelligence have highlighted the potential of protein language models (pLMs) to capture similar protein properties. Unlike MSAs, pLMs can make inferences from single sequences, without the need for a set of aligned sequences. In this...

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Share to Amino Acid Sequence
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Hemagglutinin Glycoproteins, Influenza Virus

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Identifiers

PMID: 41669667
DOI: 10.1093/nargab/lqag018
PMCID: PMC12884077

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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