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Article

Genomic and clinicopathological characteristics of low oncotype recurrent score breast cancers with subsequent metastasis.

Histopathology - 1 Jun 2026

Liu Liu, Graff Stephanie L, Hacking Sean, Cheng Liang, Wang Yihong

Abstract excerpt

AIMS: Oncotype DX has played a critical role in guiding treatment decisions for hormone receptor (HR)-positive, HER2-negative early-stage breast cancer. Clinically, a subset of patients with low Oncotype recurrent score (RS) will still progress on standard therapy and ultimately develop metastasis. Our goal was to explore potential molecular mechanisms, including specific genetic alterations and pathway activity...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 41664643
DOI: 10.1111/his.70115

Genes

PIK3CA
ESR1
TP53
CDKN2A
CTNNB1
EMSY
KIT
KMT2C
MAP3K1
MYC
SPEN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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