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Key amino acids in RNA polymerase and helicase proteins regulate RNA synthesis efficiency in porcine reproductive and respiratory syndrome virus

16 May 2025

Abstract excerpt

Porcine reproductive and respiratory syndrome virus (PRRSV) exhibits rapid evolution due to its high mutation rate and frequent recombination, posing significant challenges for disease control. In this study, we investigated the molecular mechanisms underlying strain-specific variations in PRRSV replication phenotypes. Using reverse genetics and molecular biology approaches, we established a non-infectious...

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PMID: 40383149
DOI: 10.1016/j.jbc.2025.110247

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