Article
A Novel Motif in the 3'-UTR of PRRSV-2 Is Critical for Viral Multiplication and Contributes to Enhanced Replication Ability of Highly Pathogenic or L1 PRRSV.
Viruses - 18 Jan 2022
Xiong Junyao, Cui Xingyang, Zhao Kuan, Wang Qian, Huang Xinyi, Li Dongyan, Yu Fang, Yang Yongbo, Liu Di, Tian Zhijun, Cai Xuehui, An Tongqing
Abstract excerpt
Highly pathogenic porcine reproductive and respiratory syndrome virus (HP-PRRSV) with enhanced replication capability emerged in China and has become dominant epidemic strain since 2006. Up to now, the replication-regulated genes of PRRSV have not been fully clarified. Here, by swapping the genes or elements between HP-PRRSV and classical PRRSV based on infectious clones, NSP1, NSP2, NSP7, NSP9 and 3'-UTR are...
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