Diagnostic utility of genetic alterations in distinguishing IDH-wildtype glioblastoma from lower-grade gliomas: Insight from next-generation sequencing analysis of 479 cases.

doi:10.1111/bpa.13234

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Diagnostic utility of genetic alterations in distinguishing IDH-wildtype glioblastoma from lower-grade gliomas: Insight from next-generation sequencing analysis of 479 cases.

Brain pathology (Zurich, Switzerland) - 1 Sept 2024

Lee Boram, Hwang Soohyun, Bae Hyunsik, Choi Kyue-Hee, Suh Yeon-Lim

Abstract excerpt

The accurate diagnosis and classification of gliomas are essential for appropriate treatment planning and prognosis prediction. This study aimed to investigate the molecular diagnostics of IDH-wildtype diffuse astrocytic gliomas and identify potential genetic variants that could differentiate glioblastoma (GBM) from lower-grade gliomas when DNA methylation analysis is not feasible. In total, 479 H3-and...

Topics

Humans
Male
Female
Middle Aged
Brain Neoplasms
Adult
Isocitrate Dehydrogenase
Glioblastoma
Glioma
Aged
High-Throughput Nucleotide Sequencing

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Young Adult

Adolescent

PTEN Phosphohydrolase

Child

ErbB Receptors

Prognosis

Source

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Identifiers

PMID: 38217295
DOI: 10.1111/bpa.13234
PMCID: PMC11328351

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