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Article

Identification of prognostic markers related to homologous recombination deficiency in cholangiocarcinoma using CoxBoost and LASSO machine learning techniques.

Frontiers in immunology - 1 Jan 2026

Liu Yan, Zhou Cheng, Shen Tianhao, Yu Xue, Li Qiuying, Jiang Tinghui, Li Wei, Zhu Yongqiang

Abstract excerpt

Background: Cholangiocarcinoma (CHOL) is a highly aggressive malignancy with a poor prognosis. Homologous recombination deficiency (HRD) is associated with genomic instability and cancer progression, making it a potential therapeutic target. The aim of this study is to develop novel potential prognostic biomarkers and construct an HRD-based prognostic risk prediction model for CHOL to enhance clinical precision...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 41646851
DOI: 10.3389/fimmu.2026.1615657
PMCID: PMC12867883

Genes

BBOX1
KLHL33
MN1
OR51A4
TRDN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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