Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

How do genetic polymorphisms influence the efficacy of age-related macular degeneration treatments? A systematic review and meta-analysis.

Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie - 1 Jul 2026

Chen Kai-Yang, Chan Hoi-Chun, Chan Chi-Ming

Abstract excerpt

BACKGROUND: Age-related macular degeneration (AMD) has considerable global burden, being a major cause of vision loss. Subsequently, genetic predisposition holds a role in this case by contributing to disease susceptibility. Polymorphisms in genes such as Complement Factor H (CFH) and Age-Related Maculopathy Susceptibility 2 (ARMS2) play a key role as risk factors for AMD. This systematic review and meta-analysis...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Angiogenesis Inhibitors
Share to Complement Factor H

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genetic Predisposition to Disease

Share to Macular Degeneration

Share to Polymorphism, Genetic

Share to Polymorphism, Single Nucleotide

Share to Proteins

Share to Risk Factors

Source

Identifiers

PMID: 41642305
DOI: 10.1007/s00417-025-07058-3

Genes

ARMS2
CFH

Variants

rs1061170
rs1061170

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

How do genetic polymorphisms influence the efficacy of age-related macular degeneration treatments? A systematic review and meta-analysis.PMID 41642305Read ↗

Association of the Complement Factor H Y402H Polymorphism and Response to Anti-Vascular Endothelial Growth Factor Treatment in Age-Related Macular Degeneration: An Updated Meta-Analysis.Semantic proximity Read ↗

Investigation of genetic base in the treatment of age-related macular degeneration.Semantic proximity Read ↗

Genetics and Age-Related Macular Degeneration: A Practical Review for Clinicians.Semantic proximity Read ↗

Systematic review and meta-analysis of the association between complement factor H Y402H polymorphisms and age-related macular degeneration.Semantic proximity Read ↗

The molecular genetic basis of age-related macular degeneration: an overview.Semantic proximity Read ↗

Genetic associations of anti-vascular endothelial growth factor therapy response in age-related macular degeneration: a systematic review and meta-analysis.Semantic proximity Read ↗

Genetic insights into age-related macular degeneration: controversies addressing risk, causality, and therapeutics.Semantic proximity Read ↗

Impact of age-related maculopathy susceptibility 2, high-temperature requirement A serine peptidase 1, and complement factor H genetic variants on clinical phenotypes of age-related macular degeneration.Semantic proximity Read ↗

Meta-analysis of the pharmacogenetics of ARMS2 A69S polymorphism and the response to advanced age-related macular degenerationSemantic proximity Read ↗

Association analysis of CFH and ARMS2 gene polymorphisms in a Brazilian cohort with age-related macular degeneration.Semantic proximity Read ↗

Genetic and environmental risk factors for age-related macular degeneration in persons 90 years and older.Semantic proximity Read ↗

Complement factor H Val62Ile variant and risk of age-related macular degeneration: a meta-analysis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.