Elevated T Cell Immunoreceptor with Ig and ITIM Domains (TIGIT) Expression and Immune Cell Dysfunction Characterize Complex Proteins Associated With SET1 (COMPASS)-Like Complex Gene-Mutated Pancreatic Ductal Adenocarcinoma (PDAC).

doi:10.1016/j.modpat.2026.100972

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Elevated T Cell Immunoreceptor with Ig and ITIM Domains (TIGIT) Expression and Immune Cell Dysfunction Characterize Complex Proteins Associated With SET1 (COMPASS)-Like Complex Gene-Mutated Pancreatic Ductal Adenocarcinoma (PDAC).

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc - 1 Apr 2026

Zhang Shungang, Daniels Elaina R, McGue Jake, Sudharshan Ranga, Kim Hongsun C, Thomas Dafydd G, Krishnan Santhoshi, Frankel Timothy L, Hissong Erika, Rao Arvind, Assarzadegan Naziheh, Shi Jiaqi

Abstract excerpt

Pancreatic ductal adenocarcinoma (PDAC) is highly resistant to immune therapies. Limited biomarkers, such as mismatch repair proteins, have been used to identify those who may respond to immunotherapy. We identified a subset of aggressive PDACs (⁓25%) carrying mutations in the complex of proteins associated with SET1-like complex genes (CLCGs), which can be used as new biomarkers for targeted immunotherapy. In...

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PMID: 41638576
DOI: 10.1016/j.modpat.2026.100972
PMCID: PMC13077644

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CD4
TIGIT

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