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Mutations and structural variants arising during double-strand break repair.

Proceedings of the National Academy of Sciences of the United States of America - 10 Feb 2026

Dalin Simona, Webster Sophie, Sugawara Neal, Wu Qiuqin, Zhang Shu, Macias Carmen, Sapède Elena, Cui Tracy, Liang Victoria, Tran Laura, Beroukhim Rameen, Haber James E

Abstract excerpt

Double-strand break (DSB) repair is highly mutagenic compared to normal replication. In budding yeast, repair of an HO (homothallism) endonuclease-induced DSB at the mating-type α locus (MATα) can be repaired by using an ectopic heterochromatic HMR::Kl-URA3 donor, producing MAT::Kl-URA3. Among MAT::Kl-Ura3- mutations arising during repair, 50% are base-pair substitutions. 30% are 1-bp indels in short...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 41637452
DOI: 10.1073/pnas.2504584123
PMCID: PMC12891019

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