Article
Homing of a DNA endonuclease gene by meiotic gene conversion in Saccharomyces cerevisiae.
Nature - 28 May 1992
Gimble F S, Thorner J
Abstract excerpt
An unusual protein splicing reaction joins the N-terminal segment (A) and the C-terminal segment (C) of the 119K primary translation product (ABC) of the yeast VMA1 gene to yield a 69K vacuolar H(+)-ATPase subunit (AC) and an internal 50K polypeptide (B). This 50K protein is a site-specific DNA endonuclease that shares 34% identity with the homothallic switching endonuclease. The site cleaved by the VMA1-derived...
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