Article
Elevated homocysteine level and folate deficiency associated with increased overall risk of carcinogenesis: meta-analysis of 83 case-control studies involving 35,758 individuals.
PloS one - 1 Jan 2015
Zhang Donghong, Wen Xuemei, Wu Wei, Guo Ye, Cui Wei
Abstract excerpt
BACKGROUND: Results of the association of folate metabolism and carcinogenesis are conflicting. We performed a meta-analysis to examine the effect of the interaction of serum concentration of homocysteine (Hcy), folate, and vitamin B12 and 5,10-methylenetetrahydrofolate reductase (MTHFR) polymorphism on risk of cancer overall. METHOD: Two reviewers independently searched for all published studies of Hcy and...
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