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MAVE-NN: learning genotype-phenotype maps from multiplex assays of variant effect.

Genome biology - 15 Apr 2022

Tareen Ammar, Kooshkbaghi Mahdi, Posfai Anna, Ireland William T, McCandlish David M, Kinney Justin B

Abstract excerpt

Multiplex assays of variant effect (MAVEs) are a family of methods that includes deep mutational scanning experiments on proteins and massively parallel reporter assays on gene regulatory sequences. Despite their increasing popularity, a general strategy for inferring quantitative models of genotype-phenotype maps from MAVE data is lacking. Here we introduce MAVE-NN, a neural-network-based Python package that...

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PMID: 35428271
DOI: 10.1186/s13059-022-02661-7
PMCID: PMC9011994

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