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Article

Diagnostic and immunological roles of leptin gene rs7799039 polymorphism and cytokines in COVID-19, HCV, and dual infection.

Scientific reports - 2 Feb 2026

Sakr Amany A, Ahmed Amr E, Hasona Nabil A, Abdel-Hamid Rasha M, Faisal Asmaa Salman, Shaaban Elsaeed E, Mohamed Sahar, Abbas Abbas Mohamed, Mohamed Amal A

Abstract excerpt

The identification of reliable diagnostic biomarkers is essential for improving the early detection, prognosis, and management of viral infections. Interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-α), and Interferon-gamma (IFN-γ) are key cytokines involved in immune regulation and inflammatory responses, playing a pivotal role in the pathogenesis of hepatitis C virus (HCV), coronavirus disease 2019...

Topics

Humans
Leptin
Polymorphism, Single Nucleotide
Coinfection
COVID-19
Cytokines
Hepatitis C
Tumor Necrosis Factor-alpha
SARS-CoV-2
Interferon-gamma
Biomarkers

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Male

Interleukin-6

Female

Hepacivirus

Middle Aged

Source

Open in PubMed Open full text

Identifiers

PMID: 41629381
DOI: 10.1038/s41598-026-35418-4
PMCID: PMC12864950

Genes

TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-41629381-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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