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Article

Comparative genomic analysis of Clostridioides difficile isolates from symptomatic and asymptomatic paediatric patients.

Microbial genomics - 1 Feb 2026

Tu Lewen, Wang Runjie, Liu Gaojie, Liu Rulan, Mei Yongchao, Wang Xufei, Ye Lin, Xiao Fangfei, Wang Lu, Yu Guangjun, Wang Yizhong, Niu Xiangna, Zhang Ting, Li Xiaolu

Abstract excerpt

Clostridioides difficile infection (CDI) imposes a substantial clinical burden in paediatric populations. However, the high prevalence of asymptomatic colonization, especially in children under 2 years of age, complicates the distinction between true infection and non-pathogenic carriage. This diagnostic uncertainty hinders appropriate treatment decisions and complicates infection prevention efforts. A 6-year...

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PMID: 41627987
DOI: 10.1099/mgen.0.001610
PMCID: PMC13293320

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