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Genomic and phenotypic insight into Clostridioides difficile RT027 isolates from China reveals diverse virulence associated with clinical symptoms.

Emerging microbes & infections - 1 Dec 2026

Wang Wenjia, Lin Shan, Luo Yun, Shao Chunhong, Shi Qikai, Shao Jing, Chen Yu, Hu Hui, Wan Shuangshuang, Song Xiaojun, Jin Dazhi, Jin Yan

Abstract excerpt

Clostridioides difficile (C. difficile) ribotype 027 (RT027) has caused severe outbreaks in North America and Europe over the past 20 years. However, RT027 infections are rare in Asia, particularly in China, with limited severe cases. To clarify its molecular and phenotypic features, we investigated 11 RT027 isolates collected from Shandong, China. Whole-genome sequencing, comparative transcriptomics, CRISPR-Cas...

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Identifiers

PMID: 41843435
DOI: 10.1080/22221751.2026.2637287
PMCID: PMC12997489

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