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Article

Comprehensive defect detection in mouse embryos and the heart by combining automated phenotyping with novel population averages and atlases.

Differentiation; research in biological diversity - 1 Jan 2026

Martin Ella M M A, Drover Kyle, Shpak Anton, Horner Neil R, O'Reilly Victoria, Cocking Emma, Greasby Joelene A, Iyer Kavitha R, Arkell Ruth, Dunwoodie Sally L, Chapman Gavin

Abstract excerpt

Micro-CT has become the standard for the assessment of malformations in mouse embryos because it allows the visualisation of internal structures in the context of the intact embryo. Statistical comparison of volume differences is possible via manual segmentation of organs of interest from micro-CT scans, but this process is slow and laborious. Automated registration-based methods now exist that make the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41621112
DOI: 10.1016/j.diff.2026.100936

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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