Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

From physiopathology to treatment of familial hypercholesterolemia: Existing and emerging pharmacotherapies.

Pharmacological reviews - 1 Mar 2026

Cicero Arrigo F G, Mahjoubin-Tehran Maryam, Reiner Željko, Eid Ali H, Jamialahmadi Tannaz, Sahebkar Amirhossein

Abstract excerpt

Familial hypercholesterolemia (FH) is a hereditary disorder with a semidominant inheritance pattern, characterized by elevated levels of low-density lipoprotein cholesterol, which significantly increases the risk of early atherosclerosis-related cardiovascular disease. This review discusses the genetics, epidemiology, diagnosis, and novel therapeutic approaches for FH. Mutations in the LDL receptor gene are the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Anticholesteremic Agents
Share to Cholesterol, LDL

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to FH gene

Share to LDLR gene

Share to Hyperlipoproteinemia Type II

Share to Mutation

Share to Proprotein Convertase 9

Share to Receptors, LDL

Source

Identifiers

PMID: 41616414
DOI: 10.1016/j.pharmr.2025.100110

Genes

FH
LDLR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

From physiopathology to treatment of familial hypercholesterolemia: Existing and emerging pharmacotherapies.PMID 41616414Read ↗

New Approaches in Detection and Treatment of Familial Hypercholesterolemia.Semantic proximity Read ↗

Homozygous familial hypercholesterolemia: current perspectives on diagnosis and treatment.Semantic proximity Read ↗

Familial Hypercholesterolemia: From Clinical Suspicion to Novel TreatmentsSemantic proximity Read ↗

The promising novel therapies for familial hypercholesterolemiaSemantic proximity Read ↗

Familial Hypercholesterolemia: Update and Review.Semantic proximity Read ↗

Molecular aspects of hypercholesterolemia treatment: current perspectives and hopes.Semantic proximity Read ↗

Consensus document on diagnosis and management of familial hypercholesterolemia from the Italian Society for the Study of Atherosclerosis (SISA).Semantic proximity Read ↗

My Approach to the Patient With Familial Hypercholesterolemia.Semantic proximity Read ↗

The severe hypercholesterolemia phenotype: clinical diagnosis, management, and emerging therapies.Semantic proximity Read ↗

Evidence for improved survival with treatment of homozygous familial hypercholesterolemiaSemantic proximity Read ↗

Molecular pathology of familial hypercholesterolemia, related dyslipidemias and therapies beyond the statins.Semantic proximity Read ↗

Old challenges and new opportunities in the clinical management of heterozygous familial hypercholesterolemia (HeFH): The promises of PCSK9 inhibitors.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.