Article
New Approaches in Detection and Treatment of Familial Hypercholesterolemia.
Current cardiology reports - 1 Dec 2015
Hartgers Merel L, Ray Kausik K, Hovingh G Kees
Abstract excerpt
Familial hypercholesterolemia (FH) is an autosomal dominant genetic disorder that clinically leads to increased low density lipoprotein-cholesterol (LDL-C) levels. As a consequence, FH patients are at high risk for cardiovascular disease (CVD). Mutations are found in genes coding for the LDLR, apoB, and PCSK9, although FH cannot be ruled out in the absence of a mutation in one of these genes. It is pivotal to...
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