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Identification of the genetic basis of a CO2-dependent Staphylococcus aureus small-colony variant isolated from pacemaker leads.

Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy - 1 Feb 2026

Negishi Tatsuya, Higuma Yuuki, Takeda Aika, Hachiro Ayaka, Natori Tatsuya, Horiuchi Kazuki, Ishimine Nau, Uehara Takeshi, Matsumoto Takehisa

Abstract excerpt

PURPOSE: Small-colony variants (SCVs) are a slow-growing subset of bacteria that exhibit unusual colony morphology and unique biochemical characteristics. They are associated with chronic and persistent infections. CO2-dependent SCVs of Staphylococcus aureus have been rarely isolated from clinical specimens. This study aimed to characterize the CO2-dependent phenotype of S. aureus SCV isolated from pacemaker...

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PMID: 41611170
DOI: 10.1016/j.jiac.2026.102917

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