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Article

Fe-S cluster deficiency drives small colony variant formation in persistent infections.

Journal of advanced research - 1 Feb 2026

Chen Tianchi, Ye Zhiyi, Huang Weiyi, Zhang Qi, Jiang Feng, Yang Ziyu, Jian Ying, Wang Yanan, Xiang Guoxiu, Liu Qian, Shen Hao, Li Min, He Lei

Abstract excerpt

INTRODUCTION: Small colony variants (SCVs) of Staphylococcus aureus (S. aureus) are associated with persistent infections and poor clinical outcomes. The mechanisms driving stable SCV formation remain poorly understood, particularly concerning metabolic adaptations. This study explores the in-host evolutionary dynamics of S. aureus and identifies a novel genetic determinant linked to SCV formation. OBJECTIVES: To...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 40381909
DOI: 10.1016/j.jare.2025.05.018
PMCID: PMC12869195

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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