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Article

A Multiomic Approach Integrating Genomic and Metabolomic Data Highlights Colorectal Cancer Pathways.

Journal of proteome research - 6 Feb 2026

Iliou Aikaterini, Chekmeneva Elena, Pinto Rui Climaco, Koukouzeli Fotini E, Ntounias Yiannis, Georgakopoulou Konstantina, Pouliou Marialena, Agelopoulos Marios, Tsilidis Konstantinos K, Gunter Marc J, Elliott Paul, Griffin Julian L, Dehghan Abbas, Klinakis Apostolos, Mikros Emmanuel, Tzoulaki Ioanna

Abstract excerpt

Numerous genetic variants have been identified by genome-wide association studies as being associated with colorectal cancer (CRC) risk. Metabolome-wide association analysis was performed for 187 CRC-associated genetic variants using genomic data and untargeted 1H nuclear magnetic resonance urine metabolomics from 1951 Airwave Health Monitoring Study participants. We identified statistically significant...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 41603468
DOI: 10.1021/acs.jproteome.5c00459
PMCID: PMC12887983

Genes

RHPN2
BMP2
MAP2K5
SLC6A18

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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