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Extracellular Vesicles Secreted by Mesenchymal Stromal Cells Exert Opposite Effects to Their Cells of Origin in Murine Sodium Dextran Sulfate-Induced Colitis.

Frontiers in immunology - 1 Jan 2021

Tolomeo Anna Maria, Castagliuolo Ignazio, Piccoli Martina, Grassi Michele, Magarotto Fabio, De Lazzari Giada, Malvicini Ricardo, Caicci Federico, Franzin Chiara, Scarpa Melania, Macchi Veronica, De Caro Raffaele, Angriman Imerio, Viola Antonella, Porzionato Andrea, Pozzobon Michela, Muraca Maurizio

Abstract excerpt

Several reports have described a beneficial effect of Mesenchymal Stromal Cells (MSCs) and of their secreted extracellular vesicles (EVs) in mice with experimental colitis. However, the effects of the two treatments have not been thoroughly compared in this model. Here, we compared the effects of MSCs and of MSC-EV administration in mice with colitis induced by dextran sulfate sodium (DSS). Since cytokine...

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Identifiers

PMID: 33927713
DOI: 10.3389/fimmu.2021.627605
PMCID: PMC8076641

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