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Article

Age- and Genotype-Associated Specific Expression of IL-1 and TNF Receptors on Immunocompetent Cells.

International journal of molecular sciences - 13 Jan 2026

Zhukova Julia, Lopatnikova Julia, Vasilyev Filipp, Alshevskaya Alina, Lipa Darya, Sennikov Sergey

Abstract excerpt

Aging is accompanied by a chronic, low-grade inflammatory state known as "inflammaging," largely driven by dysregulated signaling of pro-inflammatory cytokines like IL-1 and TNF-α. The biological impact of these cytokines is modulated by the expression of their cellular receptors, which is influenced by genetic polymorphisms. However, the interplay between age, genetic variation, and cell-type-specific receptor...

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Identifiers

PMID: 41596456
DOI: 10.3390/ijms27020807
PMCID: PMC12841339

Genes

TNF
IL1R1
IL1R2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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