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Functional Detection of TNF Receptor Family Members by Affinity-Labeled Ligands

25 Jul 2017

Abstract excerpt

Aberrant expression of TNF family of cytokines has been linked to human diseases, and biologics targeting their signaling have become the best selling drugs globally. However, functional detection with labeled ligands for accurate detection of TNFR family of receptor-expressing target tissues or cell types remains to be developed. Here we show that TNF receptor family members are heat-stable and can be recognized...

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PMID: 28761167
DOI: 10.1038/s41598-017-06343-4

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