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Article

Obesity-related RNA m6A demethylase gene FTO rs1421085 is associated with neuroticism in a longitudinal birth cohort study.

Journal of neural transmission (Vienna, Austria : 1996) - 1 Jul 2026

Kurrikoff Triin, Eensoo Diva, Harro Jaanus

Abstract excerpt

Recent studies have suggested the involvement of brain RNA m6A methylation in stress response. One of the key players in the RNA m6A regulation is the demethylation catalysed by the fat mass and obesity-associated protein FTO, encoded by the fat mass and obesity-associated gene. Based on findings that experimental manipulation of the RNA m6A methylation in animal experiments can affect anxiety, and given that the...

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Share to Alpha-Ketoglutarate-Dependent Dioxygenase FTO
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PMID: 41591493
DOI: 10.1007/s00702-026-03108-0

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FTO

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