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Chemical Investigation of the Global Regulator veA-Overexpressed Mutant of an Arctic Strain Aspergillus sydowii MNP-2.

Marine drugs - 9 Jan 2026

Gong Qing, Wang Wei, Zhao Yujie, Wang Xiaoying, Bai Xuelian, Zhang Huawei

Abstract excerpt

A growing body of evidence indicates that artificial manipulation of transcriptional regulation is a powerful approach to activate cryptic biosynthetic gene clusters (BGCs) of secondary metabolites (SMs) in fungi. In this study, one mutant strain MNP-2-OE::veA was constructed by overexpressing the global transcription regulator veA in an Arctic-derived strain Aspergillus sydowii MNP-2. Chemical investigation of...

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PMID: 41590731
DOI: 10.3390/md24010034
PMCID: PMC12843210

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