Missense and Intronic Variants in HNF1A Affect Prostate Cancer Aggressiveness in Patients with Biochemical Recurrence.

doi:10.7150/ijms.127638

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Article

Missense and Intronic Variants in HNF1A Affect Prostate Cancer Aggressiveness in Patients with Biochemical Recurrence.

International journal of medical sciences - 1 Jan 2026

Tung Min-Che, Lin Yung-Wei, Lai Chung-Howe, Lin Chia-Yen, Chang Lun-Ching, Wen Yu-Ching, Yang Shun-Fa, Chien Ming-Hsien

Abstract excerpt

Prostate cancer (PCa) is a genetically and phenotypically heterogeneous disease, and further advancements in PCa biomarker discovery are urgently required. Hepatocyte nuclear factor 1 A (HNF1A), a transcription factor, plays a critical role in PCa progression after biochemical recurrence (BCR). However, studies investigating the impact of HNF1A genetic variants on PCa are scarce. Therefore, in this study, we...

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