Article
Genetic variants in epithelial-mesenchymal transition genes as predictors of clinical outcomes in localized prostate cancer.
Carcinogenesis - 12 Aug 2020
Deng Yang, Xie Kunlin, Logothetis Christopher J, Thompson Timothy C, Kim Jeri, Huang Maosheng, Chang David W, Gu Jian, Wu Xifeng, Ye Yuanqing
Abstract excerpt
BACKGROUND: Epithelial-mesenchymal transition (EMT) plays a pivotal role in the progression of prostate cancer (PCa). However, little is known about genetic variants in the EMT pathway as predictors of aggressiveness, biochemical recurrence (BCR) and disease reclassification in localized PCa. PATIENTS AND METHODS: In this multistage study, we evaluated 5186 single nucleotide polymorphisms (SNPs) from 264 genes...
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