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Article

Desmosomal junctions are necessary for adult sinus node function.

Cardiovascular research - 1 Aug 2016

Mezzano Valeria, Liang Yan, Wright Adam T, Lyon Robert C, Pfeiffer Emily, Song Michael Y, Gu Yusu, Dalton Nancy D, Scheinman Melvin, Peterson Kirk L, Evans Sylvia M, Fowler Steven, Cerrone Marina, McCulloch Andrew D, Sheikh Farah

Abstract excerpt

AIMS: Current mechanisms driving cardiac pacemaker function have focused on ion channel and gap junction channel function, which are essential for action potential generation and propagation between pacemaker cells. However, pacemaker cells also harbour desmosomes that structurally anchor pacemaker cells to each other in tissue, but their role in pacemaker function remains unknown. METHODS AND RESULTS: To...

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Identifiers

PMID: 27097650
DOI: 10.1093/cvr/cvw083
PMCID: PMC4957488

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DSP

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