Disentangling the Immune Cell-Mediated Causal Effects of Gut Microbiota on Inflammatory Bowel Disease via Mendelian Randomization

Abstract excerpt

<title>Abstract</title> <p><bold>Introduction:</bold> Inflammatory Bowel Disease (IBD), including Crohn's Disease and Ulcerative Colitis, is a chronic intestinal inflammation that significantly impacts patients' quality of life. Recently, studies have highlighted that the gut microbiota can influence the pathogenesis of IBD by mediating immune cells. <bold>Methods</bold>:We used a two-sample bidirectional Mendeli...

Topics

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• CD4-Positive T-Lymphocytes
• Asthma
• Colitis, Ulcerative
• Crohn Disease
• Genome-Wide Association Study
• Inflammatory Bowel Diseases
• Mendelian Randomization Analysis
• Phenotype

Identifiers and source

Literature Corpus work

a6e8582c-9b6f-5b89-940d-466495ccb658

DOI

10.21203/rs.3.rs-6723420/v1