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Genetic association between gut microbiome and blood pressure and blood cell count as mediator: A two-step Mendelian randomization analysis.

Gene - 20 Oct 2024

Zhang Jiyu, He Junyi, Liao Yuhan, Xia Xinyi, Yang Fen

Abstract excerpt

BACKGROUND: Previous studies have established a genetic link between gut microbiota and hypertension, but whether blood cell count plays a mediating role in this remains unknown. This study aims to explore genetic associations and causal factors involving the gut microbiome, peripheral blood cell count, and blood pressure. METHODS: We utilized summary statistics derived from genome-wide association studies to...

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PMID: 38762013
DOI: 10.1016/j.gene.2024.148573

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