Pulmonary Solid and Granular Adenocarcinomas Expressing HepPar1/CPS1: Highly Aggressive Tumors Exhibiting Mitochondrial Adaptation to STK11 Mutations Rather Than Hepatoid Differentiation.

doi:10.1016/j.modpat.2026.100965

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Pulmonary Solid and Granular Adenocarcinomas Expressing HepPar1/CPS1: Highly Aggressive Tumors Exhibiting Mitochondrial Adaptation to STK11 Mutations Rather Than Hepatoid Differentiation.

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc - 1 Apr 2026

Febres-Aldana Christopher A, Vanderbilt Chad M, Aly Rania, Saliba Maelle, Seshan Surya V, Frosina Denise, Jungbluth Achim A, Richards Allison L, Bodd Francis, Wilson Christina, Park Kay J, Kezlarian-Sachs Brie, Ladanyi Marc, Cui Can, Rudin Charles M, Baine Marina K, Travis William D, Chang Jason C, Srivastava Amitabh, Rekhtman Natasha

Abstract excerpt

Hepatoid lung carcinomas, similar to hepatoid carcinomas of other sites, are defined as extrahepatic tumors exhibiting divergent hepatocellular differentiation. Uniquely, hepatoid carcinomas of lung origin are reported to commonly express only hepatocyte paraffin 1 (HepPar1)-a hepatocellular marker, which recognizes mitochondrial enzyme carbamoyl-phosphate synthetase-1 (CPS1). Recently, HepPar1/CPS1 was found to...

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Identifiers

PMID: 41580239
DOI: 10.1016/j.modpat.2026.100965

Genes

STK11
TTF1
CPS1

Provenance

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