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Article

Are PTTG1 variants associated with tumor characteristics and p53/Ki-67 expression in pituitary neuroendocrine tumors.

Frontiers in endocrinology - 1 Jan 2025

Baikstiene Ieva, Duseikaite Monika, Vilkeviciute Alvita, Juskiene Martyna, Makstiene Jurgita, Poskiene Lina, Tamasauskas Arimantas, Verkauskiene Rasa, Liutkeviciene Rasa, Zilaitiene Birute

Abstract excerpt

Background: Pituitary tumor-transforming gene 1 (PTTG1) is a proto-oncogene implicated in pituitary neuroendocrine tumors (PitNETs) pathogenesis through regulation of the cell cycle, genomic instability, and angiogenesis. Overexpression of PTTG1 promotes tumor growth, but the impact of its genetic variants in PitNETs size is insufficiently defined. Objective: To evaluate the impact of PTTG1 gene variants...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 41573212
DOI: 10.3389/fendo.2025.1717301
PMCID: PMC12819198

Genes

PTTG1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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