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A Mendelian Randomization Study on the Causal Associations Between Six Blood Pressure-related Hormones and Frailty

Endocrine, metabolic & immune disorders drug targets - 1 Jan 2026

Xiang Lu, Yuan Weimin, Xu Zhanxiang, Ma Juerui, Lu Qing, Jin Jing, Sun Ying

Abstract excerpt

INTRODUCTION: Observational studies suggest a link between hypertension, blood pressure- related hormones, and frailty. However, the causal nature of the association between these hormones and frailty remains unclear. This study employs Mendelian randomization (MR) to investigate the causal relationships between frailty and genetically influenced blood pressure-related hormones. METHODS: Genetic variants were...

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PMID: 41572683
DOI: 10.2174/0118715303388179251111045514

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ACE
ACE2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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