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Article

Direct image-guided convective perfusion of the bilateral thalami for gene therapy in frontotemporal dementia: technical note.

Journal of neurosurgery - 1 Mar 2026

Lonser Russell R, Rabon Matthew, Damante Mark, Elder J Bradley, Zabek Miroslaw, Cooper David L

Abstract excerpt

OBJECTIVE: Certain neurological conditions can be treated by delivering therapeutics to the thalamus, but intrathalamic perfusion properties and methods have not been tested in humans. Therefore, the aim of this study was to define the properties of intrathalamic convective gene therapy delivery by analyzing findings among patients with frontotemporal dementia (FTD) associated with granulin (GRN) mutation who...

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Frontotemporal Dementia
Genetic Therapy
Magnetic Resonance Imaging
Mutation

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PMID: 41569880
DOI: 10.3171/2025.8.JNS251410

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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