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Article

High Body Mass Index as a Causal Risk Factor for Vascular-Related Dementia: A Mendelian Randomization Study.

The Journal of clinical endocrinology and metabolism - 19 May 2026

Nordestgaard Liv Tybjærg, Luo Jiao, Emanuelsson Frida, Leyden Genevieve, Sanderson Eleanor, Davey Smith George, Christoffersen Mette, Afzal Shoaib, Benn Marianne, Nordestgaard Børge G, Tybjærg-Hansen Anne, Frikke-Schmidt Ruth

Abstract excerpt

CONTEXT: Obesity is associated with a high risk of vascular-related dementia with metabolic risk factors as potential mediators, but questions of causality remain unanswered. OBJECTIVE: We aimed to determine whether high body mass index (BMI) is a causal risk factor for vascular-related dementia, and whether any effect is mediated by hypertension, hyperlipidemia, hyperglycemia, and low-grade inflammation....

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PMID: 41568975
DOI: 10.1210/clinem/dgaf662

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