Article
Integrating genetic, transcriptional, and functional analyses to identify 5 novel genes for atrial fibrillation.
Circulation - 7 Oct 2014
Sinner Moritz F, Tucker Nathan R, Lunetta Kathryn L, Ozaki Kouichi, Smith J Gustav, Trompet Stella, Bis Joshua C, Lin Honghuang, Chung Mina K, Nielsen Jonas B, Lubitz Steven A, Krijthe Bouwe P, Magnani Jared W, Ye Jiangchuan, Gollob Michael H, Tsunoda Tatsuhiko, Müller-Nurasyid Martina, Lichtner Peter, Peters Annette, Dolmatova Elena, Kubo Michiaki, Smith Jonathan D, Psaty Bruce M, Smith Nicholas L, Jukema J Wouter, Chasman Daniel I, Albert Christine M, Ebana Yusuke, Furukawa Tetsushi, Macfarlane Peter W, Harris Tamara B, Darbar Dawood, Dörr Marcus, Holst Anders G, Svendsen Jesper H, Hofman Albert, Uitterlinden Andre G, Gudnason Vilmundur, Isobe Mitsuaki, Malik Rainer, Dichgans Martin, Rosand Jonathan, Van Wagoner David R, Benjamin Emelia J, Milan David J, Melander Olle, Heckbert Susan R, Ford Ian, Liu Yongmei, Barnard John, Olesen Morten S, Stricker Bruno H C, Tanaka Toshihiro, Kääb Stefan, Ellinor Patrick T
Abstract excerpt
BACKGROUND: Atrial fibrillation (AF) affects >30 million individuals worldwide and is associated with an increased risk of stroke, heart failure, and death. AF is highly heritable, yet the genetic basis for the arrhythmia remains incompletely understood. METHODS AND RESULTS: To identify new AF-related genes, we used a multifaceted approach, combining large-scale genotyping in 2 ethnically distinct populations,...
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