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Article

Discovering interrelated natural mutations of efflux pump KmrA from Klebsiella pneumoniae that confer increased multidrug resistance.

Protein science : a publication of the Protein Society - 1 Jun 2022

Li Ying, Ge Xizhen

Abstract excerpt

Klebsiella pneumoniae is a notorious pathogen that can cause multiorgan infections, which is difficult to treat mainly due to the widely distributed efflux pumps. Our previous research discovered the upregulation of efflux pump KmrA conferred enhanced antibiotic resistance, while the export mechanism and its natural mutations across K. pneumoniae isolates remain unclear. Herein, we analyzed the natural mutations...

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PMID: 35634772
DOI: 10.1002/pro.4323
PMCID: PMC9083138

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