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Article

Physical activity, genetic predisposition, and incident cardiovascular disease: Prospective analyses of the UK Biobank.

Journal of sport and health science - 1 Dec 2025

Ahmadi Matthew N, Mundell Hamish D, Sutherland Greg T, Hamer Mark, Sillanpää Elina, Blodgett Joanna M, Cruz Borja Del Pozo, Stamatakis Emmanuel

Abstract excerpt

BACKGROUND: It is unclear whether physical activity can benefit participants with high genetic predisposition to cardiovascular disease. We examined the joint associations of intensity-specific physical activity and genetic predisposition (based on polygenetic risk score) with incident coronary heart disease (CHD), stroke, and atrial fibrillation (AF). METHODS: This prospective cohort study included 303,950...

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Identifiers

PMID: 40355085
DOI: 10.1016/j.jshs.2025.101055
PMCID: PMC12337884

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