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Engineering Immortalized Bovine Granulosa Cells Using a Triple-Gene Approach: Mutant CDK4, Cyclin D1, and TERT.

Cell biology international - 1 Feb 2026

Bai Lanlan, Takahashi Minami, Kobayashi Jin, Eitsuka Takahiro, Matsusaka Himari, Ozaki Taku, Sugano Eriko, Tomita Hiroshi, Xu Yuan, Kawamura Kazuhiro, Nakagawa Kiyotaka, Kiyono Tohru, Fukuda Tomokazu

Abstract excerpt

Advancing reproductive technologies in livestock is essential to improve both productivity and genetic potential of cattle. Despite this importance, application of reproductive biotechnologies in cattle breeding remains limited. Bovine granulosa cells (bGCs), which are key components of the ovarian follicle, are critical in female reproduction as they produce steroid hormones and growth factors necessary for...

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Identifiers

PMID: 41562311
DOI: 10.1002/cbin.70126
PMCID: PMC12821082

Genes

TERT
CDK4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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