Dissecting the relationship between hypertensive disorders of pregnancy and branched-chain amino acids: An integrated investigation combining Mendelian randomization, transcriptomics, and machine learning.

Abstract excerpt

Empirical investigations have identified associations between elevated branched-chain amino acids (BCAAs) levels and an increased incidence of hypertensive disorders of pregnancy (HDP). The aim of this study is to rigorously explore the causal linkage between BCAAs concentrations and the risk of developing HDP. A bidirectional Mendelian randomization (MR) analysis was conducted to ascertain the causal...

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• Amino Acids, Branched-Chain
• Hypertension, Pregnancy-Induced
• Isoleucine
• Leucine
• Machine Learning