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Circular RNA circTmem241 drives group III innate lymphoid cell differentiation via initiation of Elk3 transcription

11 Aug 2022

Abstract excerpt

Abstract Innate lymphoid cells (ILCs) exert important roles in host defense, tissue repair and inflammatory diseases. However, how ILC lineage specification is regulated remains largely elusive. Here we identify that circular RNA circTmem241 is highly expressed in group III innate lymphoid cells (ILC3s) and their progenitor cells. CircTmem241 deficiency impairs ILC3 commitment and attenuates anti-bacterial...

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Circular RNAs in diseases
Eosinophilic Esophagitis
IL-33, ST2, and ILC Pathways

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 35953472
DOI: 10.1038/s41467-022-32322-z

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