Article
Biology and Clinical Management of Non-V600 BRAF Alterations in NSCLC.
Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer - 1 Apr 2026
Ortiz-Cuaran Sandra, Dupriez Laurine, Nicq Constance, Lindsay Colin R, Mazieres Julien, Santamaría David, Ambrogio Chiara, Calvayrac Olivier, Teixido Cristina, Friboulet Luc, Novello Silvia, Tabbò Fabrizio, Swalduz Aurélie, Nadal Ernest, Planchard David, Mezquita Laura, Nokin Marie-Julie
Abstract excerpt
BRAF mutations are detected in approximately 3% to 8% of patients with NSCLC. In contrast to melanoma, in which most BRAF mutations occur at the V600 codon, only approximately 35% of BRAF-mutant NSCLC tumors harbor V600 mutations. Among the remaining cases, 60% to 70% present non-V600 mutations, primarily in exons 11 and 15. BRAF mutations are classified into three classes according to their kinase activity and...
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